The regulation of shrimp metabolism by the white spot syndrome virus (WSSV)

For more than three decades, infectious diseases have been one of the major causes economic losses in global shrimp industry. One deadliest pathogens is white spot syndrome virus (WSSV), which mass mortality farmed shrimp. Various aspects WSSV pathogenicity studied, but this review, we will focus only on them, namely metabolic reprogramming. WSSV’s modulation host metabolism affects glycolysis, tricarboxylic acid (TCA) cycle, glutaminolysis and lipid metabolism. Several signaling pathways are involved regulation, including JAK-STAT, PI3K-AKT-mTOR, MAPK Ras-Raf-MEK, with PI3K-Akt-mTOR pathway particular playing a critical role activating WSSV-induced Warburg effect. Taken together, these changes benefit by facilitating replication. In summarize current knowledge regarding metabolism-related pathogenesis, discuss mechanisms reprograms its host's pathways. A deeper understanding pathways, key enzymes potentially important for development effective anti-WSSV strategies.